|
KMID : 1134820200490080796
|
|
Journal of the Korean Society of Food Science and Nutrition
2020 Volume.49 No. 8 p.796 ~ p.802
|
|
|
Inhibitory Effects of Isoderrone on Platelet Aggregation through Regulation of Cyclic Nucleotides
|
|
Shin Jung-Hae
|
|
|
Abstract
|
|
|
|
Extract of Cudrania tricuspidata is commonly used in ethnomedicine throughout Eastern Asia, and various studies have reported that Cudrania tricuspidata has physiological activities such as anti-diabetes, anti-bacterial, and anti-cancer effects. In addition, it has been reported that root extract of Cudrania tricuspidata has anti-platelet effects. Therefore, we studied the potential efficacies of this natural compound by focusing on the inhibitory effect of isoderrone from Cudrania tricuspidata on human platelet aggregation. Collagen-induced human platelet aggregation was dose-dependently inhibited by isoderrone and it suppressed collagen-induced elevation of [Ca2+]i mobilization. In addition, isoderrone inhibited collagen-induced fibronectin adhesion to αⅡb/β3. Thus, in the present study, isoderrone showed an inhibitory effect on human platelet activation, suggesting its potential use as a natural substance for preventing platelet-induced thrombosis.
|
|
|
KEYWORD
|
|
|
isoderrone, Cudrania tricuspidata, [Ca2+]i mobilization, thromboxane A2, fibronectin adhesion
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|